PU.1 can bind GATA-1 and GATA-2 C-fingers ( Liew et al., 2006 Rekhtman, Radparvar, Evans, & Skoultchi, 1999 Zhang et al., 2000). PU.1 downregulation is necessary for megakaryocyte and erythroid differentiation ( Pop et al., 2010 Stopka, Amanatullah, Papetti, & Skoultchi, 2005). PU.1 is an ETS family transcription factor expressed in myeloid and B-lineage cells and required for HSC function as well as monocyte/macrophage, B cell, neutrophil, and erythroid cell development ( Klemsz, McKercher, Celada, Van Beveren, & Maki, 1990 McKercher et al., 1996 Pop et al., 2010 Scott, Simon, Anastasi, & Singh, 1994 Scott et al., 1997 Staber et al., 2013). Bresnick, in Current Topics in Developmental Biology, 2016 4.4 PU.1 Hence, this transcription factor may act in further refining the pDC:cDC1 lineage commitment, as Etv6 deficient cDC1 were incapable of cross-priming tumor-specific T cell responses ( Lau et al., 2018).Ī.W. Additionally, the depletion of an floxed Etv6 in bone marrow cells by a tamoxifen-driven Cre recombinase revealed a development of primary cDC1 with an expression profile and chromatin structure reminiscent of pDCs, whereas cDC specific gene and chromatin signatures were downregulated ( Lau et al., 2018). In Flt3L-driven DC differentiation from bone marrow cells deficient in Etv6 expression, the differentiation of cDC1-like cells was perturbed. Etv6 was found to be expressed in cDCs, while the expression of antagonists such as Ets1 expressed by pDCs, lymphocytes and neutrophils or Ehf expressed by cDC2 was lacking. The ETS family transcription factor Etv6 (also known as TEL), originally described as a transcription factor controlling hematopoietic stem cell and progenitor cell function as well as thrombopoiesis, plays a pivotal role in shaping the cDC1 lineage ( Lau et al., 2018). Diana Dudziak, in International Review of Cell and Molecular Biology, 2019 14.1.7 Etv6 promotes cDC1-like programming of cDCs
0 kommentar(er)
